Methylamino-PEG1-acid HCl

Names

[ CAS No. ]:
1367918-21-5

[ Name ]:
Methylamino-PEG1-acid HCl

[Synonym ]:
MFCD26783686

Biological Activity

[Description]:

Methylamino-PEG1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
253.9±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₁₃NO₃

[ Molecular Weight ]:
147.172

[ Flash Point ]:
107.3±21.8 °C

[ Exact Mass ]:
147.089539

[ LogP ]:
-0.54

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.448

Methylamino-PEG1-acid HCl

Names

Biological Activity

Chemical & Physical Properties

Related Compounds