(Ser25)-Protein Kinase C (19-31)

Names

[ Name ]:
(Ser25)-Protein Kinase C (19-31)

[Synonym ]:
[Ser25]-Protein Kinase C fragment 19-31
L-Valine, L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysylglycyl-L-seryl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparaginyl-
L-Arginyl-L-phenylalanylalanylarginyllysylglycylserylleucylarginyl-L-glutaminyllysylasparaginyl-L-valine
L-Valine, L-arginyl-L-phenylalanylalanylarginyllysylglycylserylleucylarginyl-L-glutaminyllysylasparaginyl-

Biological Activity

[Description]:

[Ser25] Protein Kinase C (19-31) is a substrate of protein kinase C (PKC) (Km: 0.3 μM). [Ser25] Protein Kinase C (19-31) is derived from the pseudo-substrate regulatory domain of PKCα (19-31) with a Serine at position 25 replacing the wild-type Alanine[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Others

Signaling Pathways >> TGF-beta/Smad >> PKC

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C₆₇H₁₁₈N₂₆O₁₇

[ Molecular Weight ]:
1559.818

[ Exact Mass ]:
1558.916870

[ PSA ]:
756.67000

[ LogP ]:
-4.78

[ Index of Refraction ]:
1.656

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Protein kinase C contains a pseudosubstrate prototope in its regulatory domain.

Science 238 , 1726, (1987)

The regulatory domain of protein kinase C contains an amino acid sequence between residues 19 and 36 that resembles a substrate phosphorylation site in its distribution of basic residue recognition de...