Amprolium Hydrochloride

Names

[ CAS No. ]:
137-88-2

[ Name ]:
Amprolium Hydrochloride

[Synonym ]:
mepyrium
AmproliumHclUsp27
MFCD00078831
thiacoccid
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium Chloride Hydrochloride
AMPROLIUM HYDROCHLORIDE VETRANAL,250
AMPROLIUM HYDROCHLORIDE
Thiacoccide
Amprolium HCl
EINECS 205-307-5
Amprolium (hydrochloride)

Biological Activity

[Description]:

Amprolium hydrochloride is a coccidiostat used in poultry, is a thiamine analogue and blocks the thiamine transporter of Eimeria species by blocking thiamine uptake it prevents carbohydrate synthesis.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Melting Point ]:
241 °C

[ Molecular Formula ]:
C₁₄H₂₀Cl₂N₄

[ Molecular Weight ]:
315.241

[ Exact Mass ]:
314.106506

[ PSA ]:
55.68000

[ LogP ]:
0.04270

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7565000

CHEMICAL NAME :: 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride, monohydrochloride

CAS REGISTRY NUMBER :: 137-88-2

LAST UPDATED :: 199410

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C14-H19-N4.Cl.Cl-H

MOLECULAR WEIGHT :: 315.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 mg/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 77,21,1980

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R20/21/22

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TJ7565000

[ HS Code ]:
29335995

Articles

Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.

Food. Addit. Contam. Part. B. Surveill. 8 , 106-12, (2015)

The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test pro...

Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase.

Alcohol. Clin. Exp. Res. 33(6) , 1097-103, (2009)

Heavy alcohol consumption causes cerebellar degeneration, and the underlying mechanism is unclear. Chronic alcoholism is usually associated with thiamine deficiency (TD) which is known to induce selec...

Determination of amprolium in feed by a liquid chromatography-mass spectrometry method.

J. Pharm. Biomed. Anal. 48(5) , 1457-61, (2008)

As a consequence of the finding of veterinarian drugs in food European Community banned several compounds like coccidiostats as amprolium (APL). This antibiotic has been used as a preventive and clini...