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Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

Names

[ CAS No. ]:
137076-54-1

[ Name ]:
Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate

[Synonym ]:
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic Acid Tri-tert-butyl Ester
DOTA-tri-t-Bu-ester
DOTA-Tris(Tbu ester)
DOTA-tris-tert-butyl ester
2-(1,4,7,10-tetraaza-4,7,10-tris(((tert-butyl)-oxycarbonyl)methyl)cyclododecyl)acetic acid
TRI-TERT-BUTYL 1 4 7 10-TETRAAZACYCLODOD
DOTA-(t-butyl ester)3-CO2H
TPC-M011
DOTA-tri-tert-butyl-ester
(4,7,10-Tris{2-[(2-methyl-2-propanyl)oxy]-2-oxoethyl}-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid
2-(4,7,10-TRIS(2-TERT-BUTOXY-2-OXOETHYL)-1,4,7,10-TETRAAZACYCLODODECAN-1-YL)ACETIC ACID
[4,7,10-Tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetic acid
1,4,7-tri-Boc-10-(carboxymethyl)-1,4,7,10-tetraazacyclododecane
Tri-tert-butyl 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate
DOTA-(tert-butyl ester)3-CO2H
MFCD02259697
1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid

Biological Activity

[Description]:

DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Kaneshiro TL, et, al. Synthesis and evaluation of globular Gd-DOTA-monoamide conjugates with precisely controlled nanosizes for magnetic resonance angiography. Biomacromolecules. 2008 Oct;9(10):2742-8.

Chemical & Physical Properties

[ Density]:
1.079

[ Boiling Point ]:
632.1±55.0 °C at 760 mmHg

[ Melting Point ]:
129-131 ºC

[ Molecular Formula ]:
C28H52N4O8

[ Molecular Weight ]:
572.734

[ Flash Point ]:
336.1±31.5 °C

[ Exact Mass ]:
572.378540

[ PSA ]:
129.16000

[ LogP ]:
3.76

[ Vapour Pressure ]:
0.0±4.0 mmHg at 25°C

[ Index of Refraction ]:
1.480

MSDS

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

Synthetic Route

Precursor & DownStream