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Olivetol-d9

Names

[ CAS No. ]:
137125-92-9

[ Name ]:
Olivetol-d9

[Synonym ]:
1,3-Dihydroxy-5-pentylbenzene-d9
3,5-Dihydroxyamylbenzene-d9
5-Pentyl-1,3-benzenediol-d9
Olivetol-d9
5-n-Amylresorcinol-d9
5-n-Pentylresorcinol-d9

Biological Activity

[Description]:

Olivetol-d9 is the deuterium labeled Olivetol. Olivetol is a naturally phenol found in lichens and produced by certain insects, acting as a competitive inhibitor of the cannabinoid receptors CB1 and CB2[3]. Olivetol also inhibits CYP2C19 and CYP2D6 activi

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Jiang R, et al. Cannabidiol is a potent inhibitor of the catalytic activity of cytochrome P450 2C19. Drug Metab Pharmacokinet. 2013;28(4):332-8.;Yamaori S, et al. Cannabidiol, a major phytocannabinoid, as a potent atypical inhibitor for CYP2D6. Drug Metab

Chemical & Physical Properties

[ Molecular Formula ]:
C11H7D9O2

[ Molecular Weight ]:
189.29900

[ Exact Mass ]:
189.17200

[ PSA ]:
40.46000

[ LogP ]:
2.83050

Related Compounds