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Aptiganel hydrochloride

Names

[ CAS No. ]:
137160-11-3

[ Name ]:
Aptiganel hydrochloride

[Synonym ]:
1-(3-ethylphenyl)-1-methyl-3-naphthalen-1-ylguanidine
1-(3-Ethylphenyl)-1-methyl-2-(1-naphthyl)guanidine
N-(3-Ethylphenyl)-N-methyl-N'-1-naphthalenylguanidine
46475LV84I
Guanidine, N-(3-ethylphenyl)-N-methyl-N''-1-naphthalenyl-
Aptiganel

Biological Activity

[Description]:

Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR
Research Areas >> Neurological Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[References]

[1]. Kroppenstedt SN, Schneider GH, Thomale UW, Unterberg AW. Neuroprotective properties of aptiganel HCL (Cerestat) following controlled cortical impact injury. Acta Neurochir Suppl. 1998;71:114-116.

[2]. McBurney RN. Development of the NMDA ion-channel blocker, aptiganel hydrochloride, as a neuroprotective agent for acute CNS injury. Int Rev Neurobiol. 1997;40:173-195.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
490.9±38.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H22ClN3

[ Molecular Weight ]:
303.401

[ Flash Point ]:
250.7±26.8 °C

[ Exact Mass ]:
303.173553

[ LogP ]:
5.04

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.600

Related Compounds