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Dehydroeffusol

Names

[ CAS No. ]:
137319-34-7

[ Name ]:
Dehydroeffusol

[Synonym ]:
5-ethenyl-1-methylphenanthrene-2,7-diol
5-Ethenyl-1-methyl-2,7-phenanthrenediol
Dehydroeffusol

Biological Activity

[Description]:

Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer

[In Vitro]

Dehydroeffusol suppresses the expression of vasculogenic mimicry key gene VE-cadherin[2]. Dehydroeffusol decreases the MMP2 expression and activity in gastric cancer cells[2].

[References]

[1]. Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18.

[2]. Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287(2):98-110.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H14O2

[ Molecular Weight ]:
250.29200

[ Exact Mass ]:
250.09900

[ PSA ]:
40.46000

[ LogP ]:
4.35560

Related Compounds