Nω-Propyl-L-arginine

Names

[ Name ]:
Nω-Propyl-L-arginine

[Synonym ]:
N-(N'-Propylcarbamimidoyl)-L-ornithine
3AR
Tocris-1200
L-Ornithine, N-[(E)-amino(propylimino)methyl]-
MFCD01320455

Biological Activity

[Description]:

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Neurological Disease

[In Vivo]

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2]. Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2] Dosage: 20 mg/kg Administration: I.p. Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.

[References]

[1]. Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40(24):3869-70.

[2]. Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503(1-3):103-7.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
411.0±55.0 °C at 760 mmHg

[ Melting Point ]:
122 °C(lit.)

[ Molecular Formula ]:
C₉H₂₀N₄O₂

[ Molecular Weight ]:
216.281

[ Flash Point ]:
202.4±31.5 °C

[ Exact Mass ]:
216.158630

[ PSA ]:
111.23000

[ LogP ]:
0.11

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.550

[ Storage condition ]:
Desiccate at RT

Safety Information

[ Hazard Codes ]:
C,O

[ Risk Phrases ]:
R8:Contact with combustible material may cause fire. R34:Causes burns.

[ Safety Phrases ]:
S26-S27-S36/37/39-S45-S17

[ RIDADR ]:
UN 3264 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
5.1

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%