ER176

Names

[ Name ]:
ER176

[Synonym ]:
ER-176
N-[(2R)-2-Butanyl]-4-(2-chlorophenyl)-N-methyl-2-quinazolinecarboxamide
1CFA2S833A
2-Quinazolinecarboxamide, 4-(2-chlorophenyl)-N-methyl-N-[(1R)-1-methylpropyl]-

Biological Activity

[Description]:

ER176 is a next generation PET radioligand for imaging 18 kDa translocator protein (TSPO), a biomarker for neuroinflammation[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

ER176 shows homozygous high-affinity binders (HABs)/heterozygous mixed affinity binders (MABs) ratio for BP ND (specific-to-non-displaceable ratio of distribution volumes) of 1.2[1].

[References]

[1]. Masahiro Fujita, et al. Comparison of four 11 C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176-based on recent publications that measured specific-to-non-displaceable ratios. EJNMMI Res. 2017 Oct 16;7(1):84.

[2]. Jason C Mixdorf, et al. Alternative strategies for the synthesis of [ 11 C]ER176 for PET imaging of neuroinflammation. Appl Radiat Isot. 2021 Sep 17;178:109954.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
481.8±37.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₀H₂₀ClN₃O

[ Molecular Weight ]:
353.85

[ Flash Point ]:
245.2±26.5 °C

[ Exact Mass ]:
353.129486

[ LogP ]:
4.19

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.615