Protizinic acid

Names

[ Name ]:
Protizinic acid

[Synonym ]:
Protizinic
Pirocrid

Biological Activity

[Description]:

Protizinic acid is an orally active non-steroidal antiinflammatory agent with antiinflammatory and antipyretic activity. Protizinic acid inhibits phospholipase A2 (PLA2) activity, and the IC50 value is 210 μM[1][2].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

[Target]

PLA2:210 μM (IC50)

[In Vitro]

Protizinic acid not only inhibits the in vitro generation of leukokinin but also antagonizes to it on the receptor site of leukokinin[1].

[In Vivo]

In vivo leukokinin (LK) generation system using feline acute ischemia model, When 3 mg/kg Protizinic acid is injected twice intravenously to cats with acute cardiac ischemia, increased blood acid protease activity is inhibited and significant inhibitory action on the decrease of leukokininogen, the precursor of leukokinin, is observed[1]. Oral administration of 30 mg/kg of Protizinic acid significantly inhibits arachidonic acid-induced erythema in guinea pigs[2].

[References]

[1]. K Suzuki, et al. Effects of protizinic acid on leukokinin generation and its physiological action. Agents Actions. 1984 Jun;14(5-6):699-706.

[2]. H Ohnishi, et al. Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9.

Chemical & Physical Properties

[ Density]:
1.285g/cm3

[ Boiling Point ]:
524.6ºC at 760mmHg

[ Molecular Formula ]:
C₁₇H₁₇NO₃S

[ Molecular Weight ]:
315.39

[ Flash Point ]:
271.1ºC

[ Exact Mass ]:
315.09300

[ PSA ]:
75.07000

[ LogP ]:
4.18080

[ Vapour Pressure ]:
7.83E-12mmHg at 25°C

[ Index of Refraction ]:
1.636

Safety Information

[ HS Code ]:
2934300000

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%