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Biotin-PEG3-propionic hydrazide

Names

[ CAS No. ]:
1381861-94-4

[ Name ]:
Biotin-PEG3-propionic hydrazide

[Synonym ]:
N-(2-{2-[2-(3-Hydrazino-3-oxopropoxy)ethoxy]ethoxy}ethyl)-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
4,7,10-Trioxa-13-azaoctadecan-1-oic acid, 18-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-14-oxo-, hydrazide

Biological Activity

[Description]:

Biotin-PEG3-propionic hydrazide is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
813.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H35N5O6S

[ Molecular Weight ]:
461.576

[ Flash Point ]:
445.9±34.3 °C

[ Exact Mass ]:
461.230804

[ LogP ]:
-2.76

[ Vapour Pressure ]:
0.0±2.9 mmHg at 25°C

[ Index of Refraction ]:
1.526

[ Storage condition ]:
2-8°C

Related Compounds