VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

Names

[ Name ]:
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

[Synonym ]:
VPS34

Biological Activity

[Description]:

Vps34-IN-4 (compound 19) is a potent, selective, and orally active inhibitor of VPS34. Vps34-IN-4 inhibits the autophagy in vivo. Autophagy is a dynamic process that regulates lysosomal-dependent degradation of cellular components[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Honda A, et al. Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo. ACS Med Chem Lett. 2015;7(1):72-76.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
676.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₅N₇O

[ Molecular Weight ]:
391.47

[ Flash Point ]:
362.7±34.3 °C

[ Exact Mass ]:
391.212067

[ LogP ]:
2.59

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.686

[ Storage condition ]:
-20℃

VPS34 inhibitor 1 (Compound 19, PIK-III analogue)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds