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Sinapultide

Names

[ CAS No. ]:
138531-07-4

[ Name ]:
Sinapultide

[Synonym ]:
L-Lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysine
SP-B
L-Lysine, L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-lysyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-
sinapultide

Biological Activity

[Description]:

Sinapultide is a 21-amino-acid peptide that mimics the action of human surfactant protein-B (SP-B). Sinapultide can be used for synthetic phospholipids surfactants improvement[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[In Vitro]

Sinapultide microbubble preparation (2 μg/mL, 5 μg/mL; 24 h) combined with ultrasound (0.5 MHz, 40 s) could promote the function recovery of injured AT II cells effectively via affecting TNF-α and IL-6 levels[2].

[In Vivo]

Sinapultide-loaded microbubbles (MBs) (0.1 mg; nasal delivery; collected at 3, 6, 12 and 24 hours after LPS) improves pulmonary edema in lung injury and increases lung W/D weight in LPS-induced ALI mice[2].

[References]

[1]. Braide-Moncoeur O, et al. Peptide-based synthetic pulmonary surfactant for the treatment of respiratory distress disorders. Curr Opin Chem Biol. 2016 Jun;32:22-8.  

[2]. Liu D, et al. Sinapultide-Loaded Microbubbles Combined with Ultrasound to Attenuate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Drug Des Devel Ther. 2020 Dec 22;14:5611-5622.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
2047.1±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C126H238N26O22

[ Molecular Weight ]:
2469.399

[ Flash Point ]:
1191.9±34.3 °C

[ Exact Mass ]:
2467.830322

[ LogP ]:
14.95

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.514

Related Compounds