Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt

Names

[ Name ]:
Osteostatin (1-5) (human, bovine, dog, horse, mouse, rabbit, rat) trifluoroacetate salt

[Synonym ]:
Osteostain
PARATHYROID HORMONE-RELATED PROTEIN (107-111)
OSTEOSTATIN
MFCD00133747
PTH RELATED PEPTIDE (107-111)
OSTEOSTATIN (HUMAN,RAT)
PTHRP (107-111)
PTH-RP (107-111) (HUMAN,RAT)
PTH-RELATED PROTEIN (107-111) (HUMAN,RAT)

Biological Activity

[Description]:

Osteostatin, a fragment of parathyroid hormone-related protein (PTHrP) 107-111, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis, inhibits collagen-induced arthritis and inhibits osteoclastic bone resorption directly. Osteostatin can be used for inflammation and immunology research[1][2][3][4].

[Related Catalog]:

Signaling Pathways >> Others >> Others

[References]

[1]. Fenton AJ, et.al. A potent inhibitor of osteoclastic bone resorption within a highly conserved pentapeptide region of parathyroid hormone-related protein; PTHrP[107-111]. Endocrinology. 1991 Dec;129(6):3424-6.

[2]. Ibáñez L, et.al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551.

[3]. Lozano D, et.al. Osteostatin-loaded bioceramics stimulate osteoblastic growth and differentiation. Acta Biomater. 2010 Mar;6(3):797-803.

[4]. Nácher-Juan J, et.al. Osteostatin Inhibits Collagen-Induced Arthritis by Regulation of Immune Activation, Pro-Inflammatory Cytokines, and Osteoclastogenesis. Int J Mol Sci. 2019 Aug 7;20(16):3845.