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Hydroxy-PEG3-MS

Names

[ CAS No. ]:
139115-89-2

[ Name ]:
Hydroxy-PEG3-MS

[Synonym ]:
2-(2-(2-hydroxyethoxy)ethoxy)ethyl methanesulfonate
8-hydroxy-3,6-dioxaoctyl methanesulphonate
triethylene glycol
Hydroxy-PEG3-MS

Biological Activity

[Description]:

Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C7H16O6S

[ Molecular Weight ]:
228.26300

[ Exact Mass ]:
228.06700

[ PSA ]:
90.44000

[ LogP ]:
0.06890

Related Compounds