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(2R)-Octyl-α-hydroxyglutarate

Names

[ CAS No. ]:
1391194-67-4

[ Name ]:
(2R)-Octyl-α-hydroxyglutarate

[Synonym ]:
(4R)-4-Hydroxy-5-(octyloxy)-5-oxopentanoic acid
Pentanedioic acid, 2-hydroxy-, 1-octyl ester, (2R)-
MFCD29045545

Biological Activity

[Description]:

(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a modified form of D-isomer 2-Hydroxyglutarate.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[In Vitro]

Treatment of IDH1-WT HeLa cells with (2R)-Octyl-α-hydroxyglutarate, a modified form of 2-Hydroxyglutarate with high cellular uptake, results in a dose-dependent increase in DSBs in log-phase cells. It has been used to examine the contribution of D-2-Hydroxyglutarate to the oxidative mitochondrial processes of IDH1-mutated cancer cells[1].

[References]

[1]. Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9(375).


[Related Small Molecules]

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Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
420.5±35.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H24O5

[ Molecular Weight ]:
260.327

[ Flash Point ]:
152.3±19.4 °C

[ Exact Mass ]:
260.162384

[ LogP ]:
3.03

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.473

Related Compounds