<Suppliers Price>

CaV1.3 antagonist-1

Names

[ CAS No. ]:
1391385-57-1

[ Name ]:
CaV1.3 antagonist-1

Biological Activity

[Description]:

CaV1.3 antagonist-1 is a potent and highly selective CaV1.3 L-type calcium channel (LTCC) antagonist with an IC50 of 1.7 μM. CaV1.3 antagonist-1 inhibits CaV1.3 LTCC >600-fold more potently than CaV1.2 LTCC. CaV1.3 antagonist-1, a cyclopentyl derivative, has the potential for Parkinson's disease research[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Neurological Disease

[Target]

CaV1.3:1.7 μM (IC50)


[In Vitro]

CaV1.3 antagonist-1 (Compound 8; 5 μM) exhibits 31.2% and 4.4% inhibition for CaV1.3 and CaV1.2 channel current in HEK293 cells, respectively. This correlates with the results of the FLIPR assay[1].

[References]

[1]. Soosung Kang, et al. CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat Commun. 2012;3:1146.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H19ClN2O3

[ Molecular Weight ]:
334.80

Related Compounds