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Azido-PEG1-C2-acid

Names

[ CAS No. ]:
1393330-34-1

[ Name ]:
Azido-PEG1-C2-acid

[Synonym ]:
MFCD22574801
Propanoic acid, 3-(2-azidoethoxy)-
3-(2-Azidoethoxy)propanoic acid

Biological Activity

[Description]:

Azido-PEG1-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C5H9N3O3

[ Molecular Weight ]:
159.143

[ Exact Mass ]:
159.064392

[ LogP ]:
0.01

Related Compounds