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Fmoc-Val-Ala-PAB-OH

Names

[ CAS No. ]:
1394238-91-5

[ Name ]:
Fmoc-Val-Ala-PAB-OH

[Synonym ]:
MFCD29078523
N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide
L-Alaninamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-valyl-N-[4-(hydroxymethyl)phenyl]-

Biological Activity

[Description]:

Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
811.1±65.0 °C at 760 mmHg

[ Melting Point ]:
218 °C(dec.)

[ Molecular Formula ]:
C30H33N3O5

[ Molecular Weight ]:
515.600

[ Flash Point ]:
444.4±34.3 °C

[ Exact Mass ]:
515.242004

[ LogP ]:
4.13

[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C

[ Index of Refraction ]:
1.620

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds