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DBCO-Maleimide

Names

[ CAS No. ]:
1395786-30-7

[ Name ]:
DBCO-Maleimide

[Synonym ]:
1H-Pyrrole-1-propanamide, N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-2,5-dihydro-2,5-dioxo-
N-[3-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-3-oxopropyl]-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamide

Biological Activity

[Description]:

DBCO-Maleimide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable


[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Modified antibody and radioactive metal-labelled antibody. WO2019203191A1.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
790.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H21N3O4

[ Molecular Weight ]:
427.452

[ Flash Point ]:
431.9±32.9 °C

[ Exact Mass ]:
427.153198

[ LogP ]:
3.10

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.688

[ Storage condition ]:
-20°C

Related Compounds