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Isodunnianol

Names

[ CAS No. ]:
139726-30-0

[ Name ]:
Isodunnianol

[Synonym ]:
Isodunnianol
12-Hydroxy-drim-8-en-11-saeure-lacton
12-hydroxy-drim-8-en-11-oic acid-lactone
5,5'-Diallyl-3-(4-allylphenoxy)-2,2'-biphenyldiol
Isodrimenin
isoduinnianol
[1,1'-Biphenyl]-2,2'-diol, 5,5'-di-2-propen-1-yl-3-[4-(2-propen-1-yl)phenoxy]-
MEGPFBRAROUGQD-NHYWBVRUSA
Isodrimenine

Biological Activity

[Description]:

Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Autophagy >> Autophagy

[In Vitro]

Isodunnianol (10 µM; 6, 24 h) 在 H9C2 细胞中诱导自噬并增加 pAMPK172、pULK1555 的表达，降低 pULK1757、SQSTM2 的表达[1]。 Cell Autophagy Assay[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Induced autophagic. Western Blot Analysis[1] Cell Line: H9C2 cells Concentration: 10 µM Incubation Time: 6, 24 h Result: Significantly increased the expression of pAMPK172, pULK1555,decreased teh expression of pULK1757, SQSTM2 in a time-dependent manner.

[References]

[1]. Chen C , et al . Isodunnianol alleviates duxorubicin-induced myocardial injury by activating protective autophagy. Food Funct. 2019 May 22;10(5):2651-2657.  

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
511.2±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C27H26O3

[ Molecular Weight ]:
398.493

[ Flash Point ]:
263.0±30.1 °C

[ Exact Mass ]:
398.188202

[ PSA ]:
49.69000

[ LogP ]:
6.74

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.607

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds