Sarolaner

Names

[ Name ]:
Sarolaner

[Synonym ]:
Sarolaner [USAN]
1-(5'-((5S)-5-(3,5-Dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-3'-H-spiro(azetidine-3,1'-(2)benzofuran)-1-yl)-2-(methylsulfonyl)ethanone
Ethanone,1-(5'-((5S)-5-(3,5-dichloro-4-fluorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl)spiro(azetidine-3,1'(3'H)-isobenzofuran)-1-yl)-2-(methylsulfonyl)
Sarolaner

Biological Activity

[Description]:

Sarolaner (PF-6450567) is an orally active, broad-spectrum ectoparasiticide, has efficacy against fleas and ticks on dogs, with LC80 of 0.3 μg/mL against C. felis and an LC100 of 0.003 μg/mL against O. turicata[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Target]

LC80: 0.3μg/mL (C. felis)[1] LC100: 0.003 μg/mL (O. turicata)[1]

[References]

[1]. McTier TL, et al. Discovery of sarolaner: A novel, orally administered, broad-spectrum, isoxazoline ectoparasiticide for dogs. Vet Parasitol. 2016 May 30;222:3-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈Cl₂F₄N₂O₅S

[ Molecular Weight ]:
581.36

[ Exact Mass ]:
580.02500

[ PSA ]:
93.65000

[ LogP ]:
4.78130

[ Storage condition ]:
2-8℃