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D-threo-PPMP

Names

[ CAS No. ]:
139889-53-5

[ Name ]:
D-threo-PPMP

[Synonym ]:
d-ppmp
dl-ppmp
ppmp
D-threo-PPMP

Biological Activity

[Description]:

D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[Target]

glucosylceramide synthase[1]


[In Vitro]

D-threo-PPMP (10 μM; 72 h) decreases the MDR1 expression by 70% in KB-V0.01 cells[1].

[References]

[1]. Gouazé V, et, al. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 2005 May 1;65(9):3861-7.

[2]. Hernandez Y. Novel role of sphingolipid synthesis genes in regulating giardial encystation. Infect Immun. 2008 Jul;76(7):2939-49.

[3]. Wu X, et, al. Liquid chromatography method for quantifying D-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol (D-threo-PPMP) in mouse plasma and liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jun 6;837(1-2):44-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C29H50N2O3

[ Molecular Weight ]:
474.72

[ Exact Mass ]:
474.38200

[ PSA ]:
61.80000

[ LogP ]:
6.34710

Related Compounds