Nequinate

Names

[ Name ]:
Nequinate

[Synonym ]:
7-(Benzyloxy)-6-n-butyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Methyl Ester
7-(Benzyloxy)-6-n-butyl-3-methoxycarbonyl-4-quinolone
nequinate
MFCD00867198
methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydroquinoline-3-carboxylate
Methyl 7-(benzyloxy)-6-butyl-4-oxo-1,4-dihydro-3-quinolinecarboxylate
EINECS 237-796-6
3-Quinolinecarboxylic acid, 6-butyl-1,4-dihydro-4-oxo-7-(phenylmethoxy)-, methyl ester
7-(Benzyloxy)-6-n-butyl-4-hydroxy-3-quinolinecarboxylic Acid Methyl Ester
3-Methoxycarbonyl-6-n-butyl-7-benzyloxy-4-oxoquinoline

Biological Activity

[Description]:

Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections[1]. Nequinate inhibits xanthine oxidoreductase (XOD) activity[2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Metabolic Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Xanthine Oxidase

[In Vitro]

Xanthine oxidase (XOD) is a successful and safe drug target for lowering lower serum urate (sUA) levels , it plays an important role in the catabolism of purine Nequinate shows an inhibition of 12.0% to inhibit XOD activities[2].

[References]

[1]. D K McLoughlin, et al.Efficacy of Nequinate Against Thirteen Strains of Eimeria Tenella and the Development of a Nequinate-Resistant Strain.Avian Dis. Oct-Dec 1973;17(4):717-21.

[2]. Yanfen Niu, et al. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. J Pharmacol Sci. 2017 Nov;135(3):114-120.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
520.7±50.0 °C at 760 mmHg

[ Melting Point ]:
287.5ºC

[ Molecular Formula ]:
C₂₂H₂₃NO₄

[ Molecular Weight ]:
365.422

[ Flash Point ]:
268.7±30.1 °C

[ Exact Mass ]:
365.162720

[ PSA ]:
68.39000

[ LogP ]:
6.01

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.579

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933499090

Customs

[ HS Code ]: 2933499090

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials.

Vet. Parasitol. 76(3) , 163-71, (1998)

Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC...

Sensitivity of field isolates of Eimeria tenella to anticoccidial drugs in the chicken.

Res. Vet. Sci. 47(1) , 125-8, (1989)

Thirty isolates of Eimeria tenella obtained from broiler and breeder farms were examined for their sensitivity to anticoccidial drugs. All were sensitive to robenidine, 28 were sensitive to methyl ben...

Immunity and effect of clopidol/methyl benzoquate and robenidine before and after weaning on rabbit coccidiosis in the field.

Res. Vet. Sci. 35(2) , 211-6, (1983)

For 15 months the anticoccidial effect of 200 ppm clopidol/methyl benzoquate and of 50 ppm robenidine, and the development of immunity against five different species of Eimeria were followed in a clos...