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STK33-IN-1

Names

[ CAS No. ]:
1404437-49-5

[ Name ]:
STK33-IN-1

[Synonym ]:
N-[3-Methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-6-pyrazolo[3,4-d]pyrimidinamine
1H-Pyrazolo[3,4-d]pyrimidin-6-amine, N-[3-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-1-(4-methoxyphenyl)-

Biological Activity

[Description]:

STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[Target]

IC50: 7 nM (STK33)[1].


[In Vitro]

STK33-IN-1 (compound 1) is 2-fold selective for Aurora-B (AurB) versus STK33. STK33-IN-1 (compound 1) has proven unsuccessful in selectively killing KRAS-dependent cancer cell lines[1].

[References]

[1]. Michel Weïwer, et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
613.0±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H27N7O2

[ Molecular Weight ]:
445.52

[ Flash Point ]:
324.5±34.3 °C

[ Exact Mass ]:
445.222626

[ LogP ]:
3.12

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.674

Related Compounds