Restrictocin

Names

[ Name ]:
Restrictocin

[Synonym ]:
2H-Pyrido[3,4-b]indole-2-butanamide, 1,3,4,9-tetrahydro-N,N-dimethyl-1-(2-methylpropyl)-γ-oxo-
4-(1-Isobutyl-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)-N,N-dimethyl-4-oxobutanamide

Biological Activity

[Description]:

Restrictocin is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
577.7±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₂₉N₃O₂

[ Molecular Weight ]:
355.474

[ Flash Point ]:
303.2±30.1 °C

[ Exact Mass ]:
355.225983

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.582

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H312-H317-H332-H334

[ Precautionary Statements ]:
P261-P280-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VH4725000

Articles

The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.

Biochemistry 50(14) , 3004-13, (2011)

Restrictocin and related fungal endoribonucleases from the α-sarcin family site-specifically cleave the sarcin/ricin loop (SRL) on the ribosome to inhibit translation and ultimately trigger cell death...

Role of individual cysteine residues and disulfide bonds in the structure and function of Aspergillus ribonucleolytic toxin restrictocin.

Biochemistry 38(31) , 10052-8, (1999)

Restrictocin, produced by the fungus Aspergillus restrictus, belongs to the group of ribonucleolytic toxins called ribotoxins. It specifically cleaves a single phosphodiester bond in a conserved stem ...

Mechanism of specific target recognition and RNA hydrolysis by ribonucleolytic toxin restrictocin.

Biochemistry 40(31) , 9115-24, (2001)

Restrictocin, a member of the fungal ribotoxin family, specifically cleaves a single phosphodiester bond in the 28S rRNA and potently inhibits eukaryotic protein synthesis. Residues Tyr47, His49, Glu9...