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PC Mal-NHS carbonate ester

Names

[ CAS No. ]:
1408057-91-9

[ Name ]:
PC Mal-NHS carbonate ester

Biological Activity

[Description]:

PC Mal-NHS carbonate ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[References]

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₆N₄O₁₂

[ Molecular Weight ]:
562.48

Related Compounds