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NSC5844

Names

[ CAS No. ]:
140926-75-6

[ Name ]:
NSC5844

[Synonym ]:
N,N'-Bis-(7-chlor-[4]chinolyl)-aethylendiamin
1,2-Ethanediamine,N,N'-bis(7-chloro-4-quinolinyl)
N,N'-bis-(7-chloro-[4]quinolyl)-ethylenediamine
N1,N2-bis(7-chloroquinolin-4-yl)ethane-1,2-diamine
NSC5844
RE640

Biological Activity

[Description]:

NSC5844 is a 4-aminoquinoline derivative, with antitumor and antimalarial activity.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite
Research Areas >> Cancer
Research Areas >> Infection

[Target]

Parasite[2]


[In Vitro]

NSC5844 (Compound 10) is a 4-aminoquinoline derivative, and has antitumor activity with GI50s of 7.35 ± 0.10 μM and 14.80 ± 0.35 μM against MDA-MB-468 and MCF-7 cells, respectively[1]. NSC5844 (Compound 1) is cytotoxic to P. falciparum, inhibits the growth of chloroquine-sensitive (D-6) and -resistant (W-2) clones of P. falciparum, with IC50s of 17 and 27 nM, respectively[2].

[References]

[1]. Zhang H, et al. Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives. Biomed Pharmacother. 2008 Feb;62(2):65-9. Epub 2007 May 24.

[2]. Vennerstrom JL, et al. Bisquinolines. 1. N,N-bis(7-chloroquinolin-4-yl)alkanediamines with potential against chloroquine-resistant malaria. J Med Chem. 1992 May 29;35(11):2129-34.


[Related Small Molecules]

Hydroxychloroquine sulfate | Metronidazole | Emetine dihydrochloride hydrate | Ivermectin | Artemisinin | Levamisole (hydrochloride) | Fluralaner | RRx-001 | Avermectin | Quinidine | Bithionol | Flubendazole | Mebendazole | SQ109 | Artemether

Chemical & Physical Properties

[ Molecular Formula ]:
C20H16Cl2N4

[ Molecular Weight ]:
383.27400

[ Exact Mass ]:
382.07500

[ PSA ]:
49.84000

[ LogP ]:
5.75980

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream