<Suppliers Price>

SphK1&2-IN-1

Names

[ CAS No. ]:
1415662-57-5

[ Name ]:
SphK1&2-IN-1

Biological Activity

[Description]:

SphK1&2-IN-1 is a SphK inhibitor targeting to SphK1 and SphK2. SphK1&2-IN-1 has thermal stability[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Cardiovascular Disease
Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> SPHK

[Target]

SphK1

SphK2


[In Vitro]

SphK1&2-IN-1 (化合物 40) (10 μM) 对 SphK1 和 SphK2 的抑制率分别为 14.3% 和 26.5%[1]。 SphK1&2-IN-1 (化合物 W4) (1-100 μM) 具有良好的热稳定性[1]。

[References]

[1]. Vogt D, et al. Design, synthesis and evaluation of 2-aminothiazole derivatives as sphingosine kinase inhibitors. Bioorg Med Chem. 2014 Oct 1;22(19):5354-67.  

[2]. Nong W, et al. Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4506-4511.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H14N2O3S

[ Molecular Weight ]:
290.34

[ Storage condition ]:
-20°C


Related Compounds