<Suppliers Price>

CPDA

Names

[ CAS No. ]:
1415834-63-7

[ Name ]:
CPDA

[Synonym ]:
N-[4-[(4-Chlorophenyl)methoxy]-2-pyridinyl]-2,6-difluoro-benzeneacetamide

Biological Activity

[Description]:

CPDA is a novel potent SH2 domain-containing inositol phosphatase 2 (SHIP2) inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes.Target: SHIP2in vitro: CPDA was found to enhance insulin signaling.in vivo: CPDA greatly improves abnormal glucose metabolism in diabetic animals. CPDA was also found to improve the abnormal glucose metabolism in db/db mice.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Metabolic Disease

[References]

[1]. Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2). Eur J Med Chem. 2013 Apr;62:649-660.


[Related Small Molecules]

SHP099 hydrochloride | LB-100 | Salubrinal | Calyculin A | SF1670 | Stibogluconate sodium | TPI-1 | MSI-1436 lactate | Microcystin-LR | Sodium orthovanadate | GSK 2830371 | PTP1B-IN-2 | Rosiptor | NSC 663284(DA3003-1) | TCS 401

Chemical & Physical Properties

[ Molecular Formula ]:
C20H15ClF2N2O2

[ Molecular Weight ]:
388.79500

[ Exact Mass ]:
388.07900

[ PSA ]:
51.22000

[ LogP ]:
4.84640

[ Storage condition ]:
2-8℃

Related Compounds