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Boc-NH-PEG12-CH2CH2COOH

Names

[ CAS No. ]:
1415981-79-1

[ Name ]:
Boc-NH-PEG12-CH2CH2COOH

[Synonym ]:
3,8,11,14,17,20,23,26,29,32,35,38,41-Tridecaoxa-5-azatetratetracontan-44-oic acid, 2,2-dimethyl-4-oxo-
MFCD13185149
2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23,26,29,32,35,38,41-tridecaoxa-5-azatetratetracontan-44-oic acid

Biological Activity

[Description]:

Boc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
736.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H63NO16

[ Molecular Weight ]:
717.840

[ Flash Point ]:
399.1±32.9 °C

[ Exact Mass ]:
717.414673

[ LogP ]:
-3.01

[ Vapour Pressure ]:
0.0±5.2 mmHg at 25°C

[ Index of Refraction ]:
1.469

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds