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D-myo-Inositol-1,4,5-triphosphate trisodium

Names

[ CAS No. ]:
141611-10-1

[ Name ]:
D-myo-Inositol-1,4,5-triphosphate trisodium

[Synonym ]:
D-myo-inositol-1,4,5-trisphosphate hexasodium
Trisodium (1R,2R,3S,4R,5R,6S)-3,5,6-trihydroxy-1,2,4-cyclohexanetriyl tris[hydrogen (phosphate)]
1,2,3,4,5,6-Cyclohexanehexol, 1,2,4-tris(dihydrogen phosphate), sodium salt, (1R,2R,3S,4R,5R,6S)- (1:3)

Biological Activity

[Description]:

D-myo-Inositol-1,4,5-triphosphate sodium salt is the hexapotassium salt of D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3), which is a second messenger that stimulates the discharge of calcium from the endoplasmic reticulum.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[In Vitro]

Second messenger D-myo-Inositol 1,4,5-trisphosphate (1,4,5-IP3) is served as an inositol phosphate derivative. The dissociation constant (KD) for Pr55Gag complexed with D-myo-Inositol 1,4,5-trisphosphate (an inositol with divalent phosphate groups and devoid of lipid groups) is 2170 μM. The binding affinities of D-myo-Inositol 1,4,5-trisphosphate (KD=568 μM) and 1,3,4,5-IP4 (KD=526 μM) for matrix (MA) are almost identical[1].

[References]

[1]. Anraku K, et al. Highly sensitive analysis of the interaction between HIV-1 Gag and phosphoinositide derivatives based on surface plasmon resonance. Biochemistry. 2010 Jun 29;49(25):5109-16.  

Chemical & Physical Properties

[ Molecular Formula ]:
C6H12Na3O15P3

[ Molecular Weight ]:
486.04

[ Exact Mass ]:
485.908203

[ PSA ]:
298.89000

Related Compounds