Cav 3.2 inhibitor 4

Names

[ CAS No. ]:
1416984-93-4

[ Name ]:
Cav 3.2 inhibitor 4

Biological Activity

[Description]:

Cav 3.2 inhibitor 4 (compound 21) is a potent, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitor, with an IC50 of 0.6 μM. Cav 3.2 inhibitor 4 can be used for the research of atrial fibrillation[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel
Research Areas >> Cardiovascular Disease

[References]

[1]. Giordanetto F, et, al. Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor. Bioorg Med Chem Lett. 2013 Jan 1;23(1):119-24.  

Chemical & Physical Properties

[ Molecular Formula ]:
C21H32Cl2N4O3

[ Molecular Weight ]:
459.41

Related Compounds