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CYM 50769

Names

[ CAS No. ]:
1421365-63-0

[ Name ]:
CYM 50769

Biological Activity

[Description]:

CYM 50769 is a non-peptidic selective antagonist of neuropeptides B and W receptor 1 (NPBWR1). CYM 50769 can attenuates the NPW-23-induced cell proliferation in ATDC5. CYM 50769 can be used for researching endochondral bone formation[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

NPBWR1, GPR7[1]


[In Vitro]

CYM 50769 (1 and 3 μM; 30 min) attenuates the NPW-23-induced ATDC5 cell proliferation in a dose-dependent manner[1]. Cell Proliferation Assay Cell Line: ATDC5 (exposed with 200 ng/mL NPW-23 for 24 h)[1] Concentration: 1 and 3 μM Incubation Time: 30 min Result: Attenuated the NPW-23-induced cell proliferation in a dose-dependent manner.

[References]

[1]. Guerrero M, et al. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists. Bioorg Med Chem Lett. 2013 Feb 1;23(3):614-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H17ClN2O3

[ Molecular Weight ]:
416.86

[ Exact Mass ]:
416.09300

[ PSA ]:
53.35000

[ LogP ]:
5.31570

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H413

[ RIDADR ]:
NONH for all modes of transport

Related Compounds