C-82
Names
[ CAS No. ]:
1422253-37-9
[ Name ]:
C-82
Biological Activity
[Description]:
C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.
[Related Catalog]:
[Target]
CBP/β-catenin[1]
[In Vitro]
C-82 is an active form of PRI-724. C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs[1].
[In Vivo]
PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile[1].
[Cell Assay]
The culture-activated hepatic stellate cells (HSCs) are treated with or without C-82 (3, 10 μM) for 5 days. Medium change is not performed after C-82 treatment. Cell viability is examined using XTT based Cell Proliferation Kit[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C33H34N6O4
[ Molecular Weight ]:
578.66
[ Storage condition ]:
2-8°C