<Suppliers Price>

(2S,3S)-E1R

Names

[ CAS No. ]:
1424832-57-4

[ Name ]:
(2S,3S)-E1R

Biological Activity

[Description]:

(2S,3S)-E1R (Compound 2d) is an enantiomer of E1R. (2S,3S)-E1R is a sigma-1 receptor positive allosteric modulator (Sig1R PAM) for the treatment of cognition/memory disorders[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Sigma Receptor

[In Vitro]

Sigma-1 receptor plays an important role in neuronal plasticity, a process implicated in the pathophysiology of neuropsychiatric diseases, such as Alzheimer’s disease, major depressive disorders, and schizophrenia[1].

[References]

[1]. Veinberg G, et al. Synthesis and biological evaluation of 2-(5-methyl-4-phenyl-2-oxopyrrolidin-1-yl)-acetamide stereoisomers as novel positive allosteric modulators of sigma-1 receptor. Bioorg Med Chem. 2013 May 15;21(10):2764-71.

Chemical & Physical Properties

[ Molecular Formula ]:
C13H16N2O2

[ Molecular Weight ]:
232.28

Related Compounds