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L-690,330

Names

[ CAS No. ]:
142523-38-4

[ Name ]:
L-690,330

[Synonym ]:
HMS3266J07
L-690,330
Amperozide hydrochloride

Biological Activity

[Description]:

L-690330 is a competitive inhibitor of inositol monophosphatase (IMPase) with a Kis of 0.27 and 0.19 μM for recombinant human and bovine IMPase, 0.30 and 0.42 μM for human and bovine frontal cortex IMPase, respectively, exhibits 10-fold more sensitive than mouse and rat IMPase[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
Research Areas >> Others

[Target]

Ki: 0.27 μM (Recombinant human IMPase), 0.19 μM (Recombinant bovine IMPase), 0.30 μM (Human frontal cortex IMPase), 0.42 μM (Bovine frontal cortex IMPase)[1]


[References]

[1]. Atack JR, et al. In vitro and in vivo inhibition of inositol monophosphatase by the bisphosphonate L-690,330. J Neurochem. 1993 Feb;60(2):652-8.

Chemical & Physical Properties

[ Density]:
1.787g/cm3

[ Boiling Point ]:
696.9ºC at 760mmHg

[ Molecular Formula ]:
C8H12O8P2

[ Molecular Weight ]:
298.12400

[ Flash Point ]:
375.3ºC

[ Exact Mass ]:
298.00100

[ PSA ]:
164.14000

[ LogP ]:
0.80010

[ Vapour Pressure ]:
2.18E-20mmHg at 25°C

[ Index of Refraction ]:
1.629

Related Compounds