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Mutant IDH1-IN-2

Names

[ CAS No. ]:
1429176-69-1

[ Name ]:
Mutant IDH1-IN-2

[Synonym ]:
(4S)-3-(2-{[(1S)-1-{4-[(4,4-Difluoro-1-piperidinyl)methyl]phenyl}ethyl]amino}-4-pyrimidinyl)-4-isopropyl-1,3-oxazolidin-2-one
2-Oxazolidinone, 3-[2-[[(1S)-1-[4-[(4,4-difluoro-1-piperidinyl)methyl]phenyl]ethyl]amino]-4-pyrimidinyl]-4-(1-methylethyl)-, (4S)-

Biological Activity

[Description]:

Mutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay.Target: Mutant IDH1Mutant IDH1-IN-2 has a neomorphic activity and in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer. More bioactivity information in Patent WO 2013046136A1 (Example 224).

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
Research Areas >> Cancer

[References]

[1]. Huangshu, et al. 3-Pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH and their preparation


[Related Small Molecules]

AG-120 | Enasidenib | AGI-5198 | Vorasidenib (AG-881) | AGI-6780 | GSK864 | IDH-305 | BAY-1436032 | Mutant IDH1 inhibitor | Mutant IDH1-IN-1 | Olutasidenib

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
578.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H31F2N5O2

[ Molecular Weight ]:
459.532

[ Flash Point ]:
303.4±32.9 °C

[ Exact Mass ]:
459.244568

[ LogP ]:
2.72

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.587

[ Storage condition ]:
2-8℃

Related Compounds