Boc-O1Pen-OH * DCHA

Names

[ Name ]:
Boc-O1Pen-OH * DCHA

[Synonym ]:
Acetic acid, 2-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-
{2-[(tert-Butoxycarbonyl)amino]ethoxy}acetic acid
[2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]acetic acid
AmbotzBAA5240

Biological Activity

[Description]:

Boc-NH-PEG1-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
391.2±22.0 °C at 760 mmHg

[ Molecular Formula ]:
C₉H₁₇NO₅

[ Molecular Weight ]:
219.235

[ Flash Point ]:
190.4±22.3 °C

[ Exact Mass ]:
219.110672

[ PSA ]:
84.86000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.462

Safety Information

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%