Megakaryocytes/platelets inducing agent
Names
[ CAS No. ]:
1429321-13-0
[ Name ]:
Megakaryocytes/platelets inducing agent
Biological Activity
[Description]:
Megakaryocytes/platelets inducing agent is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia.
[Related Catalog]:
[In Vitro]
Provided is an inducing agent for megakaryocytes and/or platelets from pluripotent stem cells, the inducing agent being useful in treating diseases involving thrombopenia. A method for producing megakaryocytes and/or platelets, the method comprising: separating hematopoietic progenitor cells and cells that form a septum of a net-like structure produced by pluripotent stem cells, in the presence of a compound represented by formula (I), a tautomer of the compound, a prodrug, a pharmaceutically acceptable salt of these, or a solvate of these compounds; culturing the resulting hematopoietic progenitor cells in vitro; and differentiating the same into megakaryocytes and/or platelets[1].
[References]
[1]. METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS.WO2013051625A1.
[Related Small Molecules]
Captisol
|
Cyclosporin A
|
H2DCFDA
|
0MPTP hydrochloride
|
GW4869
|
Etomoxir
|
TD139
|
Mitoquinone mesylate
|
GSK2795039
|
JC-1
|
BAPTA-AM
|
AP 20187
|
Setanaxib (GKT137831)
|
D-Luciferin
|
Crotaline
Chemical & Physical Properties
[ Density]:
1.54±0.1 g/cm3(Predicted)
[ Molecular Formula ]:
C28H25BrN4O5S2
[ Molecular Weight ]:
641.56
[ Storage condition ]:
-20°C