<Suppliers Price>

AKT-IN-6

Names

[ CAS No. ]:
1430056-54-4

[ Name ]:
AKT-IN-6

[Synonym ]:
5-{2-[(2S)-1-Amino-3-(3-fluorophenyl)-2-propanyl]-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-1-methyl-1H-pyrazole-4-carbonitrile
MFCD30470660
1H-Pyrazole-4-carbonitrile, 5-[2-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-1-methyl-

Biological Activity

[Description]:

AKT-IN-6 (Example 13) is a potent Akt inhibitor. AKT-IN-6 inhibits Akt1, Akt2 and Akt3 with IC50s < 500nM, respectively. (patent WO2013056015A1).

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PI3K/Akt/mTOR >> Akt

[Target]

Akt1

Akt2

Akt3


[In Vitro]

Akt is a central node in cell signaling downstream of growth factors, cytokines, and other cellular stimuli. Aberrant loss or gain of Akt activation underlies the pathophysiological properties of a variety of complex diseases, including type-2 diabetes and cancer[2].

[References]

[1]. Taisheng Huang; et al.Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors. WO2013056015A1.

[2]. Manning BD, et al. AKT/PKB signaling: navigating downstream. Cell. 2007;129(7):1261-1274.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
662.5±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H20FN5O

[ Molecular Weight ]:
389.426

[ Flash Point ]:
354.5±31.5 °C

[ Exact Mass ]:
389.165192

[ LogP ]:
1.38

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Storage condition ]:
store at -20℃ for one year（Powder）

Related Compounds