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UNC 2400

Names

[ CAS No. ]:
1433200-49-7

[ Name ]:
UNC 2400

[Synonym ]:
N-[(1,6-Dimethyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-1-isopropyl-6-[6-(4-isopropyl-1-piperazinyl)-3-pyridinyl]-N-methyl-1H-indazole-4-carboxamide
1H-Indazole-4-carboxamide, N-[(1,2-dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-

Biological Activity

[Description]:

UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Signaling Pathways >> Autophagy >> Autophagy

[References]

[1]. Kyle D Konze, et al. An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol. 2013;8(6):1324-34.

[2]. Bowen Xu, et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. Blood. 2015 Jan 8;125(2):346-57.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
798.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H47N7O2

[ Molecular Weight ]:
597.793

[ Flash Point ]:
436.6±32.9 °C

[ Exact Mass ]:
597.379150

[ PSA ]:
79.50000

[ LogP ]:
4.57

[ Vapour Pressure ]:
0.0±2.8 mmHg at 25°C

[ Index of Refraction ]:
1.622

Related Compounds