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jaceidin triacetate

Names

[ CAS No. ]:
14397-69-4

[ Name ]:
jaceidin triacetate

[Synonym ]:
2-(4-Acetoxy-3-methoxyphenyl)-3,6-dimethoxy-4-oxo-4H-chromene-5,7-diyl diacetate
Flavone, 4',5,7-trihydroxy-3,3',6-trimethoxy-, triacetate
4H-1-Benzopyran-4-one, 5,7-bis(acetyloxy)-2-[4-(acetyloxy)-3-methoxyphenyl]-3,6-dimethoxy-

Biological Activity

[Description]:

Jaceidin triacetate(compound 54) is a natural compound isolated formmarulabark.Jaceidin triacetatecan inhibitSARS-CoV-2 Mpro, with theIC50of 11.9μM.Jaceidin triacetateinhibits the replication of Sars-Cov-2 Viral in Vero-E6 cells[1][2].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

11.9 μM (SARS-CoV-2 Mpro)[2]


[References]

[1]. Cádiz-Gurrea ML, et al. Enhancing the Yield of Bioactive Compounds from Sclerocarya birrea Bark by Green Extraction Approaches. Molecules. 2019;24(5):966.  

[2]. Moua Yang, et al. Inhibition of Sars-Cov-2 Viral Replication and In Vivo Thrombus Formation By a Novel Plant Flavonoid. Blood. Volume 138, Supplement 1, 23 November 2021, Page 3144

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
599.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C24H22O11

[ Molecular Weight ]:
486.425

[ Flash Point ]:
257.5±30.2 °C

[ Exact Mass ]:
486.116211

[ PSA ]:
136.80000

[ LogP ]:
0.65

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.590

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds