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ONO4059 hydrochloride

Names

[ CAS No. ]:
1439901-97-9

[ Name ]:
ONO4059 hydrochloride

[Synonym ]:
8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-, hydrochloride (1:1)
6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride (1:1)
ONO4059 hydrochloride
ONO-4059(HCl salt)
ONO-4059 (hydrochloride)

Biological Activity

[Description]:

Tirabrutinib (ONO-4059) hydrochloride is a selective and novel inhibitor of BTK with IC50 2.2 nm, Tirabrutinib binds to BTK within B cells, thereby preventing B-cell receptor signaling and impeding B-cell development.

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk
Research Areas >> Cancer

[Target]

IC50: 2.2 nM (BTK)[1].


[References]

[1]. Akintunde Akinleye et al. Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 2013, 6: 59.

[2]. Harriet S et al. A phase 1 clinical trial of the selective BTK inhibitor ONO/GS-4059 in relapsed and refractory mature B-cell malignancies. Blood 2016, 127:411-419.


[Related Small Molecules]

Acalabrutinib | GDC-0853 | Evobrutinib | AVL-292 | (±)-Zanubrutinib | ONO-4059 | BMX-IN-1 | GDC-0834 | SNS-062 | RN486 | LFM-A13 | Vecabrutinib | CGI-1746 | BMS-986195 | CNX-774

Chemical & Physical Properties

[ Molecular Formula ]:
C25H23ClN6O3

[ Molecular Weight ]:
490.941

[ Exact Mass ]:
490.152008

[ Storage condition ]:
-20℃

Safety Information

[ Hazard Codes ]:
N

Related Compounds