TFMB-(R)-2-HG

Names

[ Name ]:
TFMB-(R)-2-HG

[Synonym ]:
3-(Trifluoromethyl)benzyl (2R)-5-oxotetrahydro-2-furancarboxylate
2-Furancarboxylic acid, tetrahydro-5-oxo-, [3-(trifluoromethyl)phenyl]methyl ester, (2R)-

Biological Activity

[Description]:

TFMB-(R)-2-HG, a cell membrane-permeable version of (R)-2-HG, is a carcinogenic factor in Acute myeloid leukemia (AML).TFMB-(R)-2-HG impairs SCF ER-Hoxb8 cells differentiation in response to estrogen withdrawal[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013 Mar 29;339(6127):1621-5.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
376.3±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₁F₃O₄

[ Molecular Weight ]:
288.219

[ Flash Point ]:
175.2±22.8 °C

[ Exact Mass ]:
288.060944

[ LogP ]:
1.14

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.494

TFMB-(R)-2-HG

Names

Biological Activity

Chemical & Physical Properties

Related Compounds