TFMB-(S)-2-HG

Names

[ Name ]:
TFMB-(S)-2-HG

Biological Activity

[Description]:

TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> DNA Methyltransferase

[References]

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₁F₃O₄

[ Molecular Weight ]:
288.22

TFMB-(S)-2-HG

Names

Biological Activity

Chemical & Physical Properties

Related Compounds