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Abacavir hydroxyacetate

Names

[ CAS No. ]:
1446418-48-9

[ Name ]:
Abacavir hydroxyacetate

[Synonym ]:
Abacavir hydroxyacetate
Prurisol
UNII-B3C7MG354B
Acetic acid,2-hydroxy-,((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl ester

Biological Activity

[Description]:

Abacavir hydroxyacetate is an orally active inhibitor of IL-20 and PRINS. Abacavir hydroxyacetate reduces proliferation rate of skin in psoriasis as an immune modulator. Abacavir hydroxyacetate can be used for the research of inflammatory skin problems[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

Abacavir hydroxyacetate (10-20 mg/kg; p.o. once) effectively controls psoriasis of mice[2]. Animal Model: 6 to 8-week-old male and female SCID mice with implantation of psoriatic tissue[2] Dosage: 10 and 20 mg/kg Administration: Oral gavage; 10-20 mg/kg once Result: Decreased the concentration of PRINS and 1L-20, and reduced the lesion area of skin. Showed a better effect than methotrexate in controlling psoriasis.

[References]

[1]. Guda A, et al. Investigational drugs in phase II clinical trials for moderate to severe plaque psoriasis - potential new treatments on the horizon. Expert Opin Investig Drugs. 2018 Nov;27(11):931-939.

[2]. Menon, et al. CARBOCYCLIC NUCLEOSIDES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS. WO/2013/103601/Al.

Chemical & Physical Properties

[ Molecular Formula ]:
C16H20N6O3

[ Molecular Weight ]:
344.36800

[ Exact Mass ]:
344.16000

[ PSA ]:
128.91000

[ LogP ]:
0.63860

Related Compounds