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AG-120

Names

[ CAS No. ]:
1448347-49-6

[ Name ]:
AG-120

[Synonym ]:
AG-120
2-Pyrrolidinecarboxamide, N-[(1S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl]-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-, (2S)-
ivosidenib
N-{(1S)-1-(2-Chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl}-1-(4-cyano-2-pyridinyl)-N-(5-fluoro-3-pyridinyl)-5-oxo-L-prolinamide
UNII:Q2PCN8MAM6
(2S)-1-(4-Cyano-2-pyridinyl)-5-oxo-L-prolyl-2-(2-chlorophenyl)-N-(3,3-difluorocyclobutyl)-N2-(5-fluoro-3-pyridinyl)glycinamide

Biological Activity

[Description]:

Ivosidenib (AG-120) is a mutant isocitrate dehydrogenase 1 (IDH1) inhibitor with an IC50 of 12 nM for mouse IDH1R132H.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH)
Research Areas >> Metabolic Disease

[Target]

12 nM (mouse IDH1R132H)[1]


[References]

[1]. Agresta Samuel V, et al. (S)-N-((S)-1-(2-Chlorophenyl)-2-((3,3-difluorocyclobutyl)amino)-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide as therapeutically active compound for treating cancer characterized by a mutant allele of IDH1. From PCT Int. Appl. (2015), WO 2015127172 A1 20150827.

[2]. Gu Chong-Hui, et al. Pharmaceutical compositions of therapeutically active compounds comprising (S)-N-((S)-1-(2-chlorophenyl)-2-[(3,3-difluorocyclobutyl)amino]-2-oxoethyl)-1-(4-cyanopyridin-2-yl)-N-(5-fluoropyridin-3-yl)-5-oxopyrrolidine-2-carboxamide for treating hematologic malignancies with mutant allele of IDH1. From PCT Int. Appl. (2015), WO 2015138839 A1 20150917.


[Related Small Molecules]

Enasidenib | AGI-5198 | Vorasidenib (AG-881) | AGI-6780 | GSK864 | IDH-305 | BAY-1436032 | Mutant IDH1 inhibitor | Mutant IDH1-IN-1 | Mutant IDH1-IN-2 | Olutasidenib

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
854.3±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C28H22ClF3N6O3

[ Molecular Weight ]:
582.961

[ Flash Point ]:
470.4±34.3 °C

[ Exact Mass ]:
582.139404

[ LogP ]:
0.38

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.651

[ Storage condition ]:
-20℃

Related Compounds