Musk tibetene

Names

[ CAS No. ]:
145-39-1

[ Name ]:
Musk tibetene

[Synonym ]:
5-tert-Butyl-4,6-dinitro-1,2,3-trimethylbenzene
1-tert-butyl-4,3,5-trimethyl-2-amino-6-nitrobenzene
1,2,3-Trimethyl-5-(2-methyl-2-propanyl)-4,6-dinitrobenzene
EINECS 205-651-6
Musk tibetine
1-tert-butyl-3,4,5-trimethyl-2,6-dinitro-benzene
Musk tibetene
Musk Tebetine
Nitromusk tibetene
1-tert-Butyl-3,4,5-trimethyl-2,6-dinitrobenzene
Benzene, 1- (1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
2-tert-Butyl-1,3-dinitro-4,5,6-trimethylbenzene
Benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
Tibetene musk
1-t-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
musk tibeten

Biological Activity

[Description]:

Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Musk tibetene reveals no genotoxicity in the micronucleus test with human lymphocytes and with the human hepatoma cell line Hep G2[1]. Musk tibetene reveals a cell-transforming potential that showed a dose-dependent response in our host-mediated assay system[2].

[References]

[1]. Kevekordes S, et al. Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. Toxicol Lett. 1997 Mar 14;91(1):13-7.

[2]. Apostolidis S, et al. Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. Anticancer Res. 2002 Sep-Oct;22(5):2657-62.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
391.0±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₈N₂O₄

[ Molecular Weight ]:
266.293

[ Flash Point ]:
174.6±20.7 °C

[ Exact Mass ]:
266.126648

[ PSA ]:
91.64000

[ LogP ]:
4.68

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.544

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ7220000

CHEMICAL NAME :: Benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl-

CAS REGISTRY NUMBER :: 145-39-1

BEILSTEIN REFERENCE NO. :: 2000732

LAST UPDATED :: 199712

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C13-H18-N2-O4

MOLECULAR WEIGHT :: 266.33

WISWESSER LINE NOTATION :: WNR B1 C1 D1 ENW FX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >6 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,879,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2783 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1557 (estimated) No. of Female Employees: 276 (estimated)

Safety Information

[ HS Code ]:
2904209090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2904209090

[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%