Kinetin triphosphate

Names

[ CAS No. ]:
1450894-16-2

[ Name ]:
Kinetin triphosphate

Biological Activity

[Description]:

Kinetin triphosphate(6-Fu-ATP; KTP) is an ATP analogue that regulates or enhances kinase function with higher catalytic efficiency than its endogenous substrate, ATP. Kinetin triphosphate can be used in Parkinson's disease research[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

Kinetin triphosphate 可以作为 PINK1 的磷酸供体来识别 T257 自磷酸化位点，可以在体外 HeLa 细胞中将 PINK1 G309D 催化活性恢复到接近 WT水平[1]。

[References]

[1]. Nicholas T Hertz, et al. A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell. 2013 Aug 15;154(4):737-47.   

Chemical & Physical Properties

[ Molecular Formula ]:
C15H20N5O14P3

[ Molecular Weight ]:
587.27

Related Compounds